The ayahuasca tea is a central element in the ancient shamanic practices and rites of passage of the indigenous inhabitants of northwestern South America. caapi, alone or in combination with other plants 2. The term is also applied to the tea that is obtained by infusing in water the stems of B. caapi alkaloids to other brain disorders that may benefit from stimulation of endogenous neural precursor niches.Īyahuasca is the Quechua name used to designate Banisteriopsis caapi, a jungle liana of the Malpighiaceae family that is native to the Amazon and Orinoco river basins 1. They also expand the potential application of B. These findings suggest that modulation of brain plasticity could be a major contribution to the antidepressant effects of ayahuasca. In neurospheres prepared from progenitor cells obtained from the subventricular and the subgranular zones of adult mice brains, all compounds stimulated neural stem cell proliferation, migration, and differentiation into adult neurons. caapi, and the harmine metabolite harmol, stimulate adult neurogenesis in vitro. Here we report that harmine, tetrahydroharmine and harmaline, the three main alkaloids present in B. caapi preparations show antidepressant activity, a therapeutic effect that has been linked to hippocampal neurogenesis. Animal studies and recent clinical research suggests that B. Banisteriopsis caapi is the basic ingredient of ayahuasca, a psychotropic plant tea used in the Amazon for ritual and medicinal purposes, and by interested individuals worldwide.
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